Salmon DNA Serums Dominate Seoul's Shelves: Inside Korea's PDRN Obsession

Wellness | 2026-01-06 19:25:37
[mediK / HEALTH IN NEWS] Step into an Olive Young (올리브영) store in Seoul's bustling Myeongdong(명동) district, and shelves are lined with serums and ampoules boldly labeled "salmon DNA," "PDRN," and "Rejuran." These products have become a cornerstone of contemporary K-beauty, captivating shoppers with promises of rejuvenated, resilient skin.

Polydeoxyribonucleotide, or PDRN, is derived from highly purified DNA fragments extracted from salmon gonadal tissue, commonly referred to as salmon milt, which allows for exceptional molecular purity. Because its molecular structure closely resembles human DNA—often cited at around 98% similarity—PDRN demonstrates high biocompatibility with human tissue. This biocompatibility lies at the heart of its appeal.

Originally developed in Korean medical clinics as an injectable for wound healing and tissue regeneration, PDRN made its way into everyday cosmetics in the 2020s. What began as a clinical tool for post-procedure recovery has since evolved into a mainstream skincare ingredient, reinforcing K-beauty’s reputation for innovation.

Why Koreans Embrace PDRN

Much of the enthusiasm stems from Korea’s prevailing “slow aging” philosophy—a proactive approach that views skincare as a long-term investment rather than crisis management. By the time many reach their 30s, Koreans prioritize maintaining skin barrier strength and accelerating recovery after treatments like lasers. PDRN fits naturally into this approach, offering regenerative support alongside soothing benefits.
Its rise accelerated through social media word-of-mouth, fueled by stories of K-drama stars visiting Gangnam clinics for “Rejuran Healer” injections, a branded PDRN treatment. Market data reflects this surge: the broader skin booster category, heavily featuring PDRN, has seen robust growth in recent years.

PDRN formulations typically come in lightweight, fast-absorbing ampoules or serums—low-viscosity textures that layer effortlessly and pair well with calming or hydrating companions.

PDRN cosmetics are formulated to minimize irritation while delivering regenerative benefits, typically appearing as fast-absorbing ampoules or serums with lightweight gel textures. (Image provided by Clipart Korea)
PDRN cosmetics are formulated to minimize irritation while delivering regenerative benefits, typically appearing as fast-absorbing ampoules or serums with lightweight gel textures. (Image provided by Clipart Korea)

The Science Behind PDRN

1. Cellular Renewal

PDRN has been shown to stimulate fibroblast activity, the cells responsible for producing collagen and elastin. Studies have documented improvements in skin elasticity and hydration, alongside enhanced tissue repair through pathways involving adenosine receptors and natural DNA salvage processes.

2. Inflammation Reduction and Healing

It supports anti-inflammatory pathways, making it especially useful for post-laser redness, acne-related marks, or general skin irritation. This aligns with growing Korean interest in barrier repair amid environmental stressors.

3. Barrier Fortification

By reducing transepidermal water loss, PDRN helps shield skin from dryness and pollutants.

Cautions to Consider

Because PDRN is derived from salmon DNA, individuals with fish or seafood allergies should proceed with caution. While extensive purification removes most proteins that trigger reactions, a patch test remains essential—apply a small amount to the inner arm and monitor for 24 hours.

Additionally, combining PDRN with potent actives like retinol or AHAs/BHAs can increase sensitivity. Many users choose to alternate—using PDRN in the morning for recovery and retinol at night for renewal.

In Myeongdong's vibrant beauty emporiums, PDRN represents more than a trend—it's a bridge between clinical precision and daily ritual, embodying Korea's thoughtful, forward-looking approach to aging gracefully.

Oh Ha Eun medi·K TEAM press@themedik.kr
Copyright © 2020 mediK. All rights reserved.

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