Korean Study Shows Stopping Aspirin Is Safe for Non-Cardiac Surgery in Patients With Coronary Stents

Healthcare | 2025-10-20 16:05:17
[medi K / HEALTH IN NEWS] A Korean study has found that patients taking aspirin after a coronary artery stent procedure do not face an increased risk of major cardiovascular complications if they discontinue the medication before undergoing surgery on a non-cardiac site.

The research team, led by Professor Jung-Min Ahn at Asan Medical Center in Seoul, randomly assigned 1,010 patients who had undergone coronary artery stent insertion at least one year earlier. The participants, drawn from 30 hospitals nationwide between 2017 and 2024, were divided into groups that either continued or discontinued aspirin. The incidence of major complications within 30 days after surgery was 0.6% in the continuation group and 0.9% in the discontinuation group, with no statistically significant difference.

Patients with ischemic heart disease typically receive dual antiplatelet therapy, including aspirin and P2Y12 inhibitors, to prevent vascular restenosis. However, about 20% require non-cardiac procedures—such as abdominal, orthopedic, endoscopic, or dental surgeries—within two years of stent placement, creating challenges in deciding whether to stop or maintain aspirin preoperatively. Discontinuation raises the risk of thrombosis, while continuation heightens concerns about bleeding.

A study has found that discontinuing aspirin before non-cardiac surgery does not significantly alter the risk of major complications for patients with coronary stents. (Photo provided by ClipArtKorea)
A study has found that discontinuing aspirin before non-cardiac surgery does not significantly alter the risk of major complications for patients with coronary stents. (Photo provided by ClipArtKorea)


Both domestic and international clinical guidelines recommend maintaining aspirin unless the bleeding risk is substantial, but in practice, discontinuation is common, leading to confusion. This study provides evidence that both approaches are clinically safe, allowing decisions tailored to the patient's condition and circumstances. That said, minor bleeding tended to occur more frequently in the group that continued aspirin.

The researchers stressed the importance of shared decision-making in such scenarios, where clinicians and patients collaboratively weigh evidence and preferences to determine the treatment plan.

The study was supported by the Patient-Centered Medical Technology Optimization Research Project (PACEN), overseen by South Korea's Ministry of Health and Welfare and the Korea Health Industry Development Institute.

Lim Hye Jung / press@themedik.kr
Copyright © 2020 mediK. All rights reserved.